![]() ![]() It has been demonstrated that caloric and/or protein intrauterine undernutrition induces hypertension in offspring –. It is especially relevant when there is an association between weight reduction and catch-up growth that can predispose an individual to the development of cardio-metabolic diseases in adulthood, such as diabetes and arterial hypertension –. The consumption of insufficient calories, protein, vitamins and/or minerals during early stages of development might compromise the regulation of cardiovascular system homeostasis. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Ĭompeting interests: The authors have declared that no competing interests exist. EMC is a research fellow from Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). All relevant data are within the paper and its Supporting Information files.įunding: This work (data collection and analysis) was supported by grants from Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP). This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.ĭata Availability: The authors confirm that, for approved reasons, some access restrictions apply to the data underlying the findings. Received: MaAccepted: JPublished: August 29, 2014Ĭopyright: © 2014 Maia et al. PLoS ONE 9(8):Įditor: Rudolf Kirchmair, Medical University Innsbruck, Austria (2014) Taurine Supplementation Reduces Blood Pressure and Prevents Endothelial Dysfunction and Oxidative Stress in Post-Weaning Protein-Restricted Rats. LP rats showed an increased aortic wall/lumen ratio and taurine prevented this remodeling through a reduction in wall media thickness.Ĭitation: Maia AR, Batista TM, Victorio JA, Clerici SP, Delbin MA, Carneiro EM, et al. Taurine supplementation improved the relaxation response to acetylcholine and eNOS-derived NO production, increased EC-SOD and p-eNOS protein expression, as well as reduced ROS generation and p47 phox expression in the aortas from LPT rats. Furthermore, ROS production was enhanced while acetylcholine-induced NO release was reduced in aortas from the LP group. Protein expression of p47 phox NADPH oxidase subunit was enhanced, whereas extracellular (EC)-SOD and endothelial nitric oxide synthase phosphorylation at Ser 1177 (p-eNOS) were reduced in aortas from LP rats. There was a reduced relaxation response to acetylcholine in isolated thoracic aortic rings from the LP group that was reversed by superoxide dismutase (SOD) or apocynin incubation. LP rats showed elevated systolic, diastolic and mean arterial blood pressure versus NP rats taurine supplementation partially prevented this increase. Half of the NP and LP rats concomitantly received 2.5% taurine supplementation in the drinking water (NPT and LPT, respectively). Weaned male Wistar rats were fed normal- (12%, NP) or low-protein (6%, LP) diets for 90 days. ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |